Interstate 495 southbound was closed during the Friday afternoon commute due to a crash, the Massachusetts Department of Transportation said.
MassDOT announced just before 5 p.m. that the highway was closed at Exit 70 to Route 117.
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Authorities did not give any details about the crash or say whether anyone was injured.
Aerial footage showed a truck that appeared to have crashed off the road being pulled up onto the shoulder shortly before 5:30 p.m.
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As of around 5:45 p.m., MassDOT said all lanes had reopened. Earlier, the backup appeared to be miles long.